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In the realm of targeted therapy, the intermittent use of the PI3K// inhibitor BAY1082439 (NCT01728311) was shown to reprogram the immune microenvironment and sustain antitumor responses, particularly in PTEN-deficient cancers
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206 YinJ.SakamotoK.ZhangH.ItoZ.ImagamaS.KishidaS.et al (2009)
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