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What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis
doi:10.1056/NEJMoa2502082 Verma S, Bttcher M, Brown P, et al
It found that 12 participants who received BPC 157 injections in their knees rated their pain lower six months to a year later
Dosing and titration schedule Because cagrilintide is still investigational, there are no official prescribing guidelines yet
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