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A 2024 survey of 135 redox and metabolomics laboratories found that 77% had switched cysteine kits at least twice, citing high background from glutathione, failure to detect cysteine in low-volume serum samples, and batch-to-batch variability approaching twofold between consecutive lots
High concentrations of 4HNE have been associated with different processes such as apoptosis, cell differentiation, altered gene expression and with several diseases correlated to redox imbalance such as neurodegenerative and cardiovascular diseases, metabolic syndrome, and cancer 15
The biggest limitation is that the study cannot prove cause and effect, Sudhakaran says
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