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Kamen DL, Cooper GS, et al
The body regulates B12 absorption through intrinsic factor, a protein produced in the stomach that binds to B12 and facilitates its uptake in the terminal ileum
Less commonly, polymorphisms in the MC1R gene (common in individuals with red hair and Fitzpatrick type I skin) reduce receptor responsiveness to exogenous agonists, requiring higher doses or longer loading phases to achieve visible results
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