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Among these, ITI-214 (PDE1 inhibitors) and MK-8189 and EVP-6308 (PDE10A inhibitors) have proceeded to clinical trials, demonstrating promising therapeutic agents

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This would render oral formulations of DSIP virtually ineffective compared to nasal spray and injections [5]

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Goyal MS, Hawrylycz M, Miller JA, Snyder AZ, Raichle ME (2014) Aerobic glycolysis in the human brain is associated with development and neotenous gene expression

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Clin Chem Lab Med 2006;44:883-7

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