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The left protein is a form that is kinetically trapped during heterologous expression
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Still, dosage should be guided by lab results to support safe and effective treatment
[7] implicated 4-OH-E 2 in the induction of estrogen-responsive genes, a response that exhibited partial or no abrogation by coadministration with an antiestrogen, providing evidence for the ability of 4-OH-E 2 to carry out genetic upregulation via a pathway independent of ER signalling
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