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(Endocrinology, 2010), demonstrated a strong species-dependent effect: In rodents: High GLP-1 receptor expression in thyroid C-cells Strong cAMP signaling activation Persistent stimulation leads to tumor formation In humans and primates: Minimal or absent functional GLP-1 receptor expression in C-cells No meaningful calcitonin elevation under therapeutic exposure No observed C-cell proliferation in long-term studies Even exposure levels far exceeding clinical doses failed to reproduce rodent-like thyroid effects in primate models
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Their success helped normalize the idea of regular self-injection at home while opening the door psychologically and commercially for a wave of other compounds promising miraculous benefits
For a 200-pound person, 100 to 140 grams (about the equivalent of a chicken breast at lunch, a cup of Greek yogurt for a snack and a piece of salmon at dinner, with eggs or cottage cheese filling in the gaps)
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