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Support mitochondrial energy production Magnesium, CoQ10, L-carnitine, and alpha-lipoic acid (ALA) strengthen mitochondrial enzymes and improve ATP synthesis

Whether or not a subset of younger non-ambulatory SMA subjects might benefit from VPA treatment early in the course of their disease over a longer treatment period remains an outstanding question

Sterile water without preservative may require a shorter use window depending on the protocol and sterility requirements

This stability enables effective oral delivery of therapeutic cargo, as evidenced by MEVs-loaded insulin and curcumin retaining bioactivity and significantly enhancing oral bioavailability (Wu et al., 2022