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Arch Biochem Biophys 237:408414 Cadenas E, Boveris A, Ragan CI, Stoppani AO (1977) Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria
Mitochondrial dysfunction can activate the mitochondrial unfolded protein response (UPRmt) and integrated stress response (ISR), enhancing cellular stress adaptation and conferring resistance to chemotherapy and targeted therapies [41, 42]
A major way glutathione protects cells is through glutathione-dependent enzymes , especially glutathione peroxidases (GPx) , which use GSH to reduce peroxides (including hydrogen peroxide) into less reactive compounds
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