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Hegazi, S., Aly, R., Mesilhy, R
DNA demethylation upregulated Nrf2 expression in Alzheimers disease cellular model
Epileptogenic injuries or seizures initiate the synthesis and secretion of proinflammatory molecules such as TNF-, IL-1, and High Mobility Group Box 1 (HMGB1) in glial cells which result in decreasing seizure threshold, which further contributes to seizure precipitation, and recurrence because of rapid changes in glutamate and -aminobutyric acid (GABA) receptor phosphorylation
Levels of glutathione can also be rapidly depleted by ageing, stress, toxins and poor dietary choices
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