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Schisandra chinensis lignans suppressed the phosphorylation of key signaling molecules, including IB kinase alpha/beta (IKK/), inhibitor of nuclear factor kappa-B alpha (IB), protein kinase B (Akt), TANK-binding kinase 1 (TBK1), ERK, p38, JNK, NF-B (p65), c-Jun, and interferon regulatory factor 3 (IRF3), thereby disrupting the IKK//NF-B, MAPK/AP-1 (c-Jun) and TBK1/IRF3 pathways, which play pivotal roles in inflammation [32]
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Oxygen consumption rate (OCR) ( a ) and extracellular acidification rate (ECAR) ( b ) of HeLa cells expressing Ec STH and mito Ec STH before and after addition of 1 M antimycin A (ANT) measured in pyruvate free HEPES/DMEM +dFBS media
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