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Their results also suggested that NK1 and NK3 receptors may induce glandular effects by different mechanisms NK3 receptors are likely inducing activation of parasympathetic nerves, while NK1 may have direct effect on the glands [80]

Comprehensive toxicology evaluation revealed no lethal dose in rats receiving up to 20 mg/kg intramuscularly with 14-day observation

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As body weight decreases, total daily energy expenditure decreases, and the deficit that produced rapid early weight loss narrows