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In addition, treatment did not restore neurotrophin signaling and was associated with reductions in BDNF and NGF levels, suggesting a limited and potentially unfavorable impact on pathways involved in synaptic plasticity and neurodevelopment
The REDEFINE 1 and REDEFINE 2 Phase 3 trials used a once-weekly subcutaneous dose of cagrilintide 2.4 mg combined with semaglutide 2.4 mg, reached after roughly 16 weeks of dose titration
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