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This phenomenon is called metabolic adaptation, and it is the primary reason people regain weight after discontinuing medication

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Previous exposure to psychostimulants enhances the reinstatement of cocaine seeking by nucleus accumbens AMPA

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The post says patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 should not use GLP-1 agonists, citing animal-model data linking these agents to C-cell proliferation

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Peter Berger Editor, Alzheimers Weekly

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