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Additionally, some individuals taking Mounjaro may have pre-existing conditions that independently increase their risk of B12 deficiency, such as previous bariatric surgery or concurrent metformin use (the MHRA has highlighted that metformin can reduce vitamin B12 levels)

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For the beta diversity analyses, an analysis of similarities (ANOSIM) was performed on each of the distance/dissimilarity matrices to establish whether observed clustering by treatment group was statistically significant