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Class IC agents (e.g., flecainide, propafenone) significantly increase the risk of proarrhythmic events and mortality in patients with prior myocardial infarction or left ventricular dysfunction
The article says phentermine is approved only for short-term use, typically twelve weeks or less, partly because its appetite-suppressing effect may diminish as tolerance develops and partly because it carries a black-box warning for potential psychological dependence
These changes add up to significant savings
For instance, high-cost gene therapies cure diseases but cost $2 million per patient Medicare will cover some of these under Part B or D, raising questions of how society will afford them for many
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