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Mitochondrial metabolism and KRASMAPK axis in CRC chemoresistance Although chemotherapeutic agents such as 5-FU, oxaliplatin, and irinotecan remain central to CRC treatment, the metabolic adaptability of tumor cells continues to undermine their long-term efficacy [23]
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This method potentially offers metabolic and appetite-regulation benefits while minimising adverse effects commonly associated with standard doses. The scientific foundation of GLP-1 agonists lies in their ability to mimic the bodys natural glucagon-like peptide 1, enhancing insulin secretion while reducing glucagon levels
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