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Weight loss occurs in a dose-dependent way and exhibits a biphasic pattern: an initial quick phase induced by decreased calorie intake, followed by a slower phase indicative of metabolic tolerance and enduring behavioural modifications
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All currently marketed anti-diabetic drugs targeting DPP-4 block substrate binding by making hydrogen bonds with the anchoring residues Glu205/Glu206 and occupying the S1 hydrophobic pocket (Figure 7)
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Rare gastrointestinal symptoms might involve a burning sensation in the stomach, which should be promptly reported to a healthcare provider
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