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doi: 10.1016/j.immuni.2024.03.004 9 ConradiCShiuA

This receptor-mediated internalization dramatically improves the ratio of drug concentration in tumor tissue relative to healthy organs, reduces collateral damage to sensitive structures such as the myocardium, bone marrow, and gastrointestinal epithelium, and enables dose intensification at the tumor site without proportional increases in systemic toxicity [72]

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Design of stapled peptide-based PROTACs for MDM2/MDMX atypical degradation and tumor suppression