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Clinicians should evaluate for contraindications specific to GLP-1 receptor agonists, including: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 History of pancreatitis or gallbladder disease Severe gastroparesis or gastrointestinal disease History of suicidal ideation or behavior Pregnancy or planned pregnancy (pregnancy testing when appropriate) Diabetic retinopathy (requires monitoring in patients with diabetes) Baseline investigations should include TSH, free T4, complete metabolic panel, lipid profile, and hemoglobin A1c (if diabetic or prediabetic)

This is also true for some fungal GSTOs found in particular in Phanerochaete chrysosporium or carnosa and Trametes versicolor where the classical CPY/FA motif is replaced by a SPY[C/S] motif (Morel et al., 2009)

The goal here isn't to follow some rigid meal plan or count every macro

They also diminish appetite and cravings, aiding in blood sugar control and weight loss