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In addition, chronic Fe 2+ overload may also activate nuclear factor-kappa B (NF-B) enhancing the production of inducible nitric oxide synthase (iNOS), resulting in the increase of nitric oxide (NO), which leads to the reaction with the superoxide anion RNS
Preclinical research means studies conducted in animal models and laboratory settings
From a metabolic perspective, heterogeneity may reflect mechanism-phase mismatch
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