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The polyunsaturated nature of PUFAs enables critical signaling and membrane fluidity functions while conferring peroxidation susceptibility, rendering membranes rich in PUFA-phospholipids-synthesized by ACSL4 and LPCAT3-vulnerable to ferroptosis through iron-catalyzed Fenton reaction-mediated oxidation (116)
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Nonetheless, it restricts in part, diagnosis of idiopathic GHD and treatment with rhGH to those under 40, and thereby requires different treatments for medical issues related to age-associated, GH insufficiency
Moreover, GLP-1 and its analogs have shown positive effects in kidney protection, neuroprotection, and lipid metabolism regulation, and they hold promise in treating conditions like non-alcoholic steatohepatitis (NASH) and Alzheimer's disease
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