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Systemic neurological conditions also drive chronic muscle spasms: multiple sclerosis (MS), peripheral neuropathy, amyotrophic lateral sclerosis (ALS), and restless legs syndrome all disrupt the normal nerve-to-muscle communication pathway, producing involuntary contractions that can affect the entire body
95 % CI (-095, 117), P = 0839) (online Supplementary Fig
J Cell Mol Med 2014;18:236771
JAMA 302:25652572 Liu Q, Zerbinatti CV, Zhang J, Hoe H-S, Wang B, Cole SL, Herz J, Muglia L, Bu G (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1
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