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Studies on animals and humans have also implicated higher levels of 18-carbon or 20- and 22-carbon -3 fatty acids in the diet with slowing of some age related changes 92
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In addition, cellular experiments showed that SelP-H not only reduced intracellular ROS levels, but also reduced neurotoxicity induced by Cu/Cu-A 42 or Zn-A 42 complexes by 4060% [115, 116]
Given that most plasma serotonin is synthesized by EC cells, this suggests a degree of functional coordination between brain and gut serotonergic systems [125]
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