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Cai CX, Hribar M, Baxter S, Goetz K, Swaminathan SS, Flowers A, et al
Most Likely to Benefit From the Oral Option Have type 2 diabetes with inadequate glucose control on existing medicines Have established cardiovascular disease or high cardiovascular risk where the SOUL trial evidence directly applies Have a preference against injections needle phobia, dexterity issues, or simply a strong preference for tablets Have modest weight loss goals the oral form produces meaningful but more moderate weight reduction than higher-dose injectables Can reliably maintain the strict morning fasting routine patients whose mornings are very variable may find the once-weekly injectable more practical Are being considered for injectable GLP-1 therapy but want to trial the class first oral semaglutide can be a useful introduction Side Effects The side effect profile of oral semaglutide is similar to the injectable form, gastrointestinal symptoms are the most common experience, particularly in the early weeks of treatment
If this is a concern, your clinician can discuss options like dutasteride
These newer treatments have been making headlines, and for good reason multiple studies demonstrate weight loss of between 15% and 25% after a year
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