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Ann Intern Med (2020) 173:27886
Beyond weight loss, GLP-1 receptors exist in the ovaries and brain, potentially reducing PCOS-related hyperinsulinemia and supporting ovulation
Think of it as insurance for your muscles
Wei and colleagues (Wei et al., 2022) recently discovered that GLP-1 receptor activation inhibits this signaling pathway by modulating ROCK activity, leading to a reduction in the phosphorylation of MLC, which stabilizes the endothelial cell cytoskeleton and tight junctions by upregulating the expression of tight junction proteins such as Occludin and ZO-1
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