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What they found (summary): Development of Melanotan II as a cutaneous drug failed due to the combination of side effects Bifurcation into more selective derivatives was both scientifically and commercially successful PT-141 Bremelanotide (Vyleesi, 2019) Melanotan I Afamelanotide (Scenesse, 2014) Underground use of Melanotan II is safety-problematic Why it matters: This is the definitive historical review by the founders of the field

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DEPTOR is an endogenous inhibitor of mTOR activation that functions in a manner similar to the mTOR inhibitor and immunosuppressant rapamycin, although through a distinct mechanism of action