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Scientific References Long R3 insulin-like growth factor-1 (IGF-1) stimulates muscle cell hypertrophy Pharmacokinetics and tissue distribution of IGF-1 LR3 in preclinical models Long R3 insulin-like growth factor I (IGF-I) stimulates protein synthesis in muscle cells IGF-1 LR3: a potent analog with reduced binding to IGF-binding proteins

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Consequently, this intervention reduces the accumulation of histone lactylation and suppresses the expression of Fas, ultimately alleviating necroptotic cell death and renal impairment in DKD models ( 4 Autophagy 4.1 Autophagic signaling pathway Autophagy represents a preserved cellular mechanism by which cytoplasmic materials are engulfed within autophagosomes for lysosomal degradation and recycling (140)

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