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No study examined tolerance or dependence with extended use, and no study followed a repeated-dosing cohort beyond a few months
At the same time, DAA increased the expression of key genes of ferroptosis such as ferroptosis suppressor protein 1 (FSP1) in vivo and in vitro (36)
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Whatever few studies reported in this context advocate that GPx2 and GPx4 rather than GPx1 (major isozyme) may play a dominant role in conferring the organ-specific radioresistance [54,55,56, 67]
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