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Nature (2017) 548:4351
A notable double-blind RCT in 262 elderly subjects found that NAC (600 mg twice daily) for 6 months significantly reduced influenza-like episodes only 25% of NAC-treated subjects who seroconverted to influenza A developed clinical symptoms, compared to 79% of placebo subjects (De Flora et al., Eur Respir J, 1997) [40]
Concerning symptoms warranting immediate provider contact include severe chills unresponsive to additional clothing or heating, chills accompanied by fever above 100.4F, persistent chills lasting more than 2 weeks, or thermoregulatory symptoms that worsen over time
Metformin continues to be the first-line recommended therapy for almost all patients with type 2 diabetes The selection of medication added to metformin is based on patient preference and clinical characteristics, including presence of cardiovascular disease, heart failure and kidney disease
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