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Common adverse effects are predominantly gastrointestinal and typically emerge during dose escalation: Nausea (affecting 2050% of users initially) Vomiting and diarrhoea Constipation Abdominal pain and bloating Reduced appetite (therapeutic effect but may be excessive) Fatigue and headache Injection site reactions (redness, swelling or itching) These effects usually diminish over several weeks as the body adjusts
Author contributions MT and SG were responsible for the conceptualization
Oxidative stress is one of the critical mechanisms that lead to neuroinflammation and cell death [8,9,10]
Clinical trials have demonstrated substantial reductions in hemoglobin A1c levels (up to 2.5% reduction) in type 2 diabetes, while weight management trials showed 15-21% weight loss in adults with obesity without diabetes
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