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It is also contraindicated in patients with a history of pancreatitis or gastrointestinal issues since it increases gastrointestinal emptying time which can intensify symptoms
Given that IBS symptoms can include diarrhoea, constipation, bloating, and pain, IBS patients are understandably concerned about how GLP-1 medications might influence their sensitive digestive systems
3,4 American Association of Clinical Endocrinology guidelines recommend treatment with GLP-1RA in T2DM patients with coexisting ASCVD, high-risk for ASCVD, heart failure, or chronic kidney disease regardless of their glycemic control due to their organ protective effects
Ihnatowicz et al
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