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Blood Glucose and HbA1c Changes Observed in the Trial The 12 mg dose produced mean HbA1c reductions of approximately 2.2 percentage points (~24 mmol/mol) at 24 weeks, with some participants reaching HbA1c levels below the 48 mmol/mol diagnostic threshold for type 2 diabetes

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Eli Lilly plans to submit a Biologics License Application (BLA) not an NDA, since retatrutide is a biologic in Q1 2027, following completion of all four core TRIUMPH trials in 2026