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Ann Neurosci 26:25

This treatment promotes functional recovery in rats following complete spinal cord transection, significantly upregulating the expression of GPX4 and FTH1, while downregulating ACSL4 and COX2 expression, suggesting its potential to modulate anti-ferroptosis pathways involved in SCI recovery (Wang J

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From a pharmacological safety perspective, the adverse effect profile of retatrutide based on Phase 1 and Phase 2 clinical trial data (including the NEJM 2023 Phase 2 trial) includes: Gastrointestinal effects: Nausea, vomiting, diarrhoea, and constipation (the most commonly reported side effects in trial participants) Injection site reactions: Redness, swelling, or discomfort at the injection site Cardiovascular effects: Increases in heart rate have been observed in trial participants [21] [22] Hypoglycaemia: Particularly relevant in individuals with diabetes or those taking insulin, sulfonylureas, or other glucose-lowering agents Potential thyroid effects: GLP-1 receptor agonists have been associated with thyroid C-cell changes in rodent studies