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That is an important framing for anyone tempted to treat it as a shortcut: even in the animal work that generates the interest, the compound is one input alongside energy balance, not a replacement for it

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Assists in apoptosis or regular cell death

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Boise, L., Hinton, L., Rosen, H

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Reported EC values for MT-II in transfected cell assays fall in the sub-nanomolar to low-nanomolar range at MC1R and MC4R, roughly an order of magnitude weaker at MC3R and MC5R, and it is essentially inactive at MC2R, the adrenocorticotropin receptor

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