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6 Holy Cross Cancer Center in Kielce, Kielce, 25-734, Poland Correspondence: Robert Bucki Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2C, Bialystok, 15-222, Poland Tel + 48 85 748 5793 Email [email protected] Background: Even with considerable improvement in treatment of epithelial ovarian cancer achieved in recent years, an increasing chemotherapy resistance and disease 5-year relapse is recorded for a majority part of patients that encourages the search for better therapeutic options
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Development programs should treat metabolic state and vagal integrity as testable variables, not background noise, and incorporate them into early pharmacodynamic modeling