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We demonstrated that TrkB signalling in these neurons is essential to maintain normal locomotor behaviour consistent with the initial hyperkinetic symptoms of HD and suggested that TrkB signalling deficiency may contribute effectively to HD motor symptoms 13
Lipoic acid inhibits the production of chemerin, a molecule that is associated with obesity and metabolic syndrome
Similarly, a retrospective cohort trial, published in 2025, which included over 295,000 patients from North America, reported GLP1RA use was associated with about a 70% lower risk of incident dementia vs nonuse (HR = 0.30), significant even after statistical matching and multivariable adjustments [20]
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