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Johns Hopkins Medicine
Common side effects by peptide type Growth hormone peptides: Water retention (temporary) Lethargy initially (adapts within weeks) Carpal tunnel symptoms (rare, high doses) Insulin resistance (monitor with long-term use) IGF-1 LR3: Hypoglycemia (keep fast carbs on hand) Jaw/facial bone growth (with chronic use) Organ enlargement (long-term misuse) Healing peptides: Minimal side effects Occasionally: fatigue, headache (rare) Monitoring and bloodwork Baseline testing before starting: IGF-1 levels Thyroid panel (T3, T4, TSH) Fasting glucose and insulin Lipid panel Liver and kidney function Follow-up testing: Every 3-6 months during protocol Monitor IGF-1 (ensure not excessively elevated) Check glucose metabolism Liver/kidney function Contraindications Avoid peptides if: Active cancer (GH/IGF-1 can promote tumor growth) Diabetic without physician oversight Significant organ disease Use caution if: Family history of cancer Pre-diabetic Taking medications that affect blood sugar See our peptide safety and risks guide for comprehensive safety information
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