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Moreover, SGLT2is have been shown to reduce the incidence of cardiovascular and kidney disease in people with and without diabetes [5, 6], suggesting that these medications should be considered for prevention of cardiovascular and kidney disease, irrespective of HbA 1c levels
Mazdutide's specific oxyntomodulin-based structure gives it a somewhat different GLP-1:GCGR agonist ratio than survodutide's engineered sequenceexact ratio details aren't publicly disclosed but likely accounts for different gastrointestinal tolerability and metabolic profiles between the two
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However, baseline tests are recommended for those with risk factors, and patients with pre-existing liver enzyme elevations may benefit from repeat testing at 36 months, then annually or as clinically indicated
