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A study published in Frontiers in Endocrinology reported that these medications may increase the risk of pregnancy complications and birth defects
There is evidence to suggest that a number of more cost-effective pharmaceuticals in certain therapeutic classes are sometimes being excluded by PBMs, while less cost-effective medicines are recommended
Lyzenga-Dean highlights several drawbacks: "These drugs are expensive and rarely covered by insurance for folks who don't meet strict criteria, usually advanced diabetes." Additionally, these medications often require lifelong use to maintain results and can cause serious digestive side effects
Other parameters such as total cholesterol, low density lipoprotein cholesterol, and apolipoprotein B showed trends toward improvement, albeit nonsignificant [47]
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