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The core distinction is mechanism: semaglutide primarily stimulates GLP-1 receptors to reduce appetite and slow gastric emptying, whereas tirzepatide combines GLP-1 and GIP receptor activation to augment insulinotropic and metabolic effects
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Many peptides sold online may not meet medical-grade standards and may be incorrectly dosed, contaminated, or mislabeled, making their effects unpredictable and potentially harmful
Although our small cohort was underpowered to assess the impact of these quantitative atherosclerotic changes on clinical outcomes, these mechanisms may at least partially explain the treatment effects associated with GLP-1Ra in large-scale RCTs
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