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No large-scale, placebo-controlled, randomized trial has been published
The endocrine system requires time to recalibrate following substantial weight loss, and temporary disruptions are not uncommon
Chromium may improve insulin function
For instance, a large network meta-analysis showed that SGLT-2 inhibitors reduced hospitalization for HF and renal composite outcome more than GLP-1RA [15], and that in patients with cardiovascular disease, SGLT-2 inhibitors show significant reduction in both heart failure (HF) hospitalizations and mortality for patients with HF and reduced ejection fraction [16]
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