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Research has demonstrated that DSIP modulates the hypothalamic-pituitary-adrenal (HPA) axis, reducing basal corticotropin (ACTH) levels and blocking stress-induced ACTH release
10.3390/pharmaceutics15030865 150 RiderJ
The reduced caloric intake, combined with metabolic adaptation, can produce feelings of low energy during the first several weeks at each new dose level
the NIHR's Be Part of Research website is a useful starting point
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![PDF] Tirzepatide-Induced Injection Site Reaction](https://figures.semanticscholar.org/18fb0b8dbc04c04a7b5177d9fd87256fc7c060bb/2-Figure1-1.png)
