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51 , D1539D1548 (2023)

Lantus (Insulin Glargine) Lantus sales in 2022: $2.380 billion (2.259 billion) Company/Developer: Sanofi Date of first FDA approval: April 20, 2000 Indications Lantus is FDA-approved for: Type 1 and 2 diabetes Price of Lantus: $64 to $77 for a 10 mL (100 units/mL) vial and $96 for a pre-filled pen Why it did so well: Touted by Sanofi as the most prescribed long-acting insulin, Lantus was the companys second best-selling drug in 2022

A study by Mass Eye and Ear (which was published in JAMA Ophthalmology) found that those on semaglutide were four times more likely to develop NAION (17 of 200 diabetes patients) and seven times more likely to develop NAION if they were also obese or overweight (20 of 361 overweight or obese patients)

The subcutaneous tissue adjacent to the injury provides an optimal depot from which BPC-157 diffuses to target structures