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demonstrated that Semax activates striatal serotonergic systems raising the extracellular 5-HIAA level to ~180% of baseline within 14 hours and significantly potentiates d-amphetamine-induced dopamine release and locomotor activity, establishing its modulatory role across multiple monoamine neurotransmitter systems simultaneously

These peptides mimic the spatial conformation of the parent (native) molecules while exhibiting significantly enhanced resistance to enzymatic degradation, thereby enabling prolonged biological activity and reduced immunogenicity

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