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These findings suggest that DMF, in addition to NRF2 activation on antioxidant response, could affect L2HGDH expression, L2HG and SAM levels to modify DNA 5mC and 5hmC modifications and CBS expression in SCD erythroblasts
In addition to the nerves, nNOS is expressed in the aortic and pulmonary arteries, the coronary arteries and the atrial and ventricular myocardium
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