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Deficiency of vitamin B12 can lead to anaemia and neurological changes
Preclinical data is based on animal models
Biochemical regulation of mammalian AMP-activated protein kinase activity by NAD and NADH [PMID: 15465812] Laboratory literature summary: Biochemical regulation of mammalian AMP-activated protein kinase activity by NAD and NADH
The Phase 1 study (NCT04674306), conducted at Cleveland Clinics Main Campus in partnership with Anixa Biosciences, Inc., included 35 patients across three cohorts: Launched in 2021, the trial enrolled 26 patients in Phase 1a, four in Phase 1b, and five in Phase 1c
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