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Most symptoms occur during initial weeks and dose escalation, typically lessening as the body adapts
Factors That Affect How Fast Semaglutide Works for You Your baseline body weight influences onset speed because larger individuals often have higher baseline insulin levels and greater insulin resistance, which can delay the full appetite-suppression effect until metabolic adaptation occurs
Mol Hum Reprod
Insulin resistance and excessively high insulin levels have historically made it seemingly impossible to lose weight, Taylor said
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