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Discontinuation due to side effects ran at 7% in Phase 2 data, which is lower than Semaglutides 11% discontinuation rate despite Semaglutide having a higher reported nausea incidence at 44%
The practical result is that patients on cagrilintide (and especially semaglutide+cagrilintide) report more profound appetite suppression than either mechanism alone (Trevisan et al., 2024)
Risk increases significantly in individuals with copper metabolism disorders (Wilsons Disease)
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