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Nozhat et al., 2018
The 12 mg dose produced the largest mean weight loss, about 24.2% at 48 weeks, in the Phase 2 trial (Jastreboff et al., 2023)
In addition, zinc plays a vital role in the thyroid hormones metabolism by regulating thyrotropin-releasing hormone (TRH) and TSH synthesis and modulating the structures of essential transcription factors involved in synthesizing thyroid hormones ( Table 1 )
During this process, pre-luminal ( SULT1E1 ) and pre-glandular ( OPRK1 , SUFU , CBR3 , HPRT1 ) cells differentiate into mature luminal ( WNT7A , LGR5 , PTGS1 ) and glandular ( ITGA1 , HPGD , SLC47A1 ) cells, respectively [25]
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